Title :
Design and characterization of a multiplexed capillary-driven lab-on-chip for water quality analysis
Author :
Honrado, Carlos ; Silva, C.A. ; Tao Dong
Author_Institution :
Dept. of Ind. Electron., Univ. of Minho, Guimarães, Portugal
Abstract :
The concept of a novel point-of-care (POC) microfluidic device for water-quality analysis was presented. The device employs capillary phenomena as filling process and its design is compatible to the use of organic photodiodes for bio-sensing. Three different device conformations were described and characterized. The series model attained a small total filling time (TFT) of around 2.80s. However, as disadvantage, this conformation cannot be used in bio-chemiluminescence (BCL) reactions having multiple analytes in common. For the parallel model, a high TFT of around 86s was obtained and some advancing/receding of fluid during the filling process was observed. This could lead to weaker optical signals and higher noise in the sensing area. Regarding the parallel-series, a TFT value of 35s was attained. This is a compromise between previously studied conformations. Also, no advancing/receding of fluid has occurred and a more compact design was created, as desired for POC applications.
Keywords :
bioMEMS; biochemistry; biomedical equipment; biomedical measurement; capillarity; chemiluminescence; design; lab-on-a-chip; microfluidics; patient care; photodiodes; water quality; BCL reactions; POC applications; POC microfluidic device; TFT value; biochemiluminescence reactions; biosensing; capillary phenomena; compact design; device conformations; filling process; fluid advancing occurrence; fluid receding occurrence; lab-on-chip characterization; multiple analytes; multiplexed capillary-driven lab-on-chip design; noise; organic photodiodes; parallel model; parallel-series; point-of-care microfluidic device; series model; time 35 s; total filling time; water quality analysis; weak optical signals; Atmospheric modeling; Filling; Fluids; Microchannel; Microfluidics; Optical sensors; bio-chemiluminescence; capillary phenomena; microfluidics; point-of-care; polymer photodiode; water quality analysis;
Conference_Titel :
Medical Measurements and Applications (MeMeA), 2014 IEEE International Symposium on
Conference_Location :
Lisboa
Print_ISBN :
978-1-4799-2920-7
DOI :
10.1109/MeMeA.2014.6860084
