A quadrupolar magnetic actuation system for superparamagnetic particles

Author

Moser, Y. ; Lehnert, T. ; Gijs, M.A.M.

Author_Institution

Lab. of Microsyst., Ecole Polytech. Fed. de Lausanne, Lausanne, Switzerland

fYear

2009

fDate

21-25 June 2009

Firstpage

1226

Lastpage

1229

Abstract

We report on an innovative quadrupolar magnetic actuation system designed for performing immunoassays on-chip. Integrated magnetic microtips enable the retention and manipulation of functionalized superparamagnetic particles in a microfluidic channel. Actuation of dynamic bead plugs results in improved perfusion with sample solution thus enhanced analyte capture. The magnetic field parameters and kinetic properties of the bead plugs are discussed in detail. Improved protein capture efficiency is demonstrated with a model assay by means of fluorescent detection.

Keywords

electric connectors; electromagnetic actuators; magnetic particles; microfluidics; photodetectors; proteins; superparamagnetism; dynamic bead plugs; fluorescent detection; immunoassays on-chip; integrated magnetic microtips; kinetic property; magnetic field parameters; microfluidic channel; perfusion; protein capture efficiency; quadrupolar magnetic actuation system; superparamagnetic particles; Fluorescence; Kinetic theory; Magnetic analysis; Magnetic fields; Magnetic properties; Microfluidics; Micromagnetics; Plugs; Proteins; System-on-a-chip; Superparamagnetic particles; immunoassay; magnetic actuation; microfluidics; protein capture;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International

Conference_Location

Denver, CO

Print_ISBN

978-1-4244-4190-7

Electronic_ISBN

978-1-4244-4193-8

Type

conf

DOI

10.1109/SENSOR.2009.5285879

Filename

5285879