Title :
BiCMOS Implementation of Cell Signaling for Cell Survival/Death
Author :
Jain, Shruti ; Naik, Pradeep K. ; Bhooshan, Sunil V.
Author_Institution :
Dept. of Electron. & Commun. Eng., Jaypee Univ. of Inf. Technol., Solan, India
Abstract :
A well-structured and controlled design methodology, along with a supporting hierarchical design system, has been developed to optimally support the development effort on several programs requiring gate array and semi custom Very Large Scale Integration (VLSI) design. In this paper, we will present an application of VLSI in System Biology. This work examines signaling networks that control the survival decision treated with combinations of three primary signals the pro death cytokine, tumor necrosis factor-¿ (TNF), and the pro survival growth factors, epidermal growth factor (EGF) and insulin. We have made model by taking three inputs, than made the truth table, Boolean equation and than implement the equation using BiCMOS logic circuit.
Keywords :
BiCMOS logic circuits; VLSI; cellular biophysics; tumours; BiCMOS logic circuit; VLSI design; cell signaling; cell survival/death; epidermal growth factor; gate array; insulin; pro death cytokine; pro survival growth factors; semicustom very large scale integration; signaling networks; system biology; tumor necrosis factor-¿; BiCMOS integrated circuits; Control systems; Design methodology; Epidermis; Equations; Insulin; Neoplasms; Optimal control; Systems biology; Very large scale integration; BiCMOS; Epidermal Growth Factor; Insulin; Tumor Necrosis Factor-a;
Conference_Titel :
Signal Acquisition and Processing, 2010. ICSAP '10. International Conference on
Conference_Location :
Bangalore
Print_ISBN :
978-1-4244-5724-3
Electronic_ISBN :
978-1-4244-5725-0
DOI :
10.1109/ICSAP.2010.36
