Title :
Automatic on-chip sequential processing for bio-microsystems
Author :
Ohnishi, N. ; Satoh, W. ; Morimoto, K. ; Fukuda, J. ; Suzuki, H.
Author_Institution :
Grad. Sch. of Pure & Appl. Sci., Univ. of Tsukuba, Tsukuba, Japan
Abstract :
As a trial to realize an automatic microfluidic system, functions such as automatic valve operation, adjustment of mixing time, pH-regulation, and sensing were integrated on a chip. Microfluidic transport was achieved by capillary action. The transport and merge of solutions was controlled by gold working electrodes that functioned as valves. The mixing valve was also used as a delay line to take enough time for mixing. The pH of the mixed solution could be adjusted using an electrochemical pH-regulator, and gaseous ammonia produced from the solution could be measured using an air-gap ammonia sensor. The function of the entire system was checked in the enzymatic reaction of urea.
Keywords :
bioMEMS; biosensors; electrochemical electrodes; enzymes; gas sensors; gold; lab-on-a-chip; microfluidics; microsensors; Au; NH3; air-gap ammonia sensor; automatic microfluidic system; automatic on-chip sequential processing; bio-microsystems; capillary action; delay line; electrochemical pH-regulator; enzymatic reaction; gaseous ammonia; gold electrodes; microfluidic transport; mixing time adjustment; mixing valve; pH-regulation; urea; Air gaps; Biosensors; Chemical and biological sensors; Delay lines; Electrodes; Gas detectors; Gold; Metal-insulator structures; Microfluidics; Valves; Air-gap ammonia sensor; Automatic switching; Capillary action; Delay line; Electrowetting; Valve; pH-regulator;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International
Conference_Location :
Denver, CO
Print_ISBN :
978-1-4244-4190-7
Electronic_ISBN :
978-1-4244-4193-8
DOI :
10.1109/SENSOR.2009.5285974
