Title :
Two-dimensional label-free acetylcholine image sensor for imaging neuronal communication
Author :
Takenaga, Shoko ; Lee, Seung-Ro ; Rahman, M.M. ; Takao, Hidekuni ; Ishida, Makoto ; Sawada, Kazuaki
Author_Institution :
Dept. of Electr. & Electron. Eng., Toyohashi Univ. of Technol., Toyohashi, Japan
Abstract :
32times32 acetylcholine image sensors were successfully fabricated by using the CCD/CMOS image sensor technique, and real time imaging of acetylcholine distribution was carried out without label and a huge measurement. Acetylcholine imaging technology has a lot of potential for the early stage of Alzheimer´s disease, the release mechanism between terminal neurons. In addition, the proposed sensor is a very unique device due to not only determine quantity but also acquire real time imaging of behavior of biological matter. Therefore, the sensor has an infinite of possibility as a new tool in medical and biological field.
Keywords :
CCD image sensors; CMOS image sensors; biochemistry; biomedical equipment; biomedical imaging; chemical sensors; neurophysiology; organic compounds; pH measurement; Alzheimer´s disease; CCD image sensor; CMOS image sensor; biological matter; neuronal communication; pH sensor; real time imaging; two-dimensional label-free acetylcholine image sensor; Alzheimer´s disease; Biochemistry; Biomedical imaging; Biosensors; CMOS technology; Charge coupled devices; Charge transfer; Charge-coupled image sensors; Fluorescence; Image sensors; ACh; CCD; enzyme reaction; image sensor;
Conference_Titel :
Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International
Conference_Location :
Denver, CO
Print_ISBN :
978-1-4244-4190-7
Electronic_ISBN :
978-1-4244-4193-8
DOI :
10.1109/SENSOR.2009.5285980
