Gray Box Modelling of Arterial Vasoaction

Gray box modelling of physiological systems involves constructing a model structure based on physical knowledge of the system and model parameterisation using numerical techniques. This paper presents a gray box model of arterial vasoaction (the process of constricting and dilating blood vessels in order to maintain an appropriate level of blood pressure and blood flow). The model structure is built in accordance with the physical system. The initial parameterisation was manual, with the model consequently optimised using gradient techniques and genetic algorithms. The model was validated by demonstrating good correlation between experimental results and model output