Title :
Novel detection platform for Alzheimer´s amyloid-beta using magnetic beads in electrochemical impedance spectroscopy
Author :
Kyeong-Sik Shin ; Moo Jong Kim ; Soo Hyun Lee ; Ji Yoon Kang
Author_Institution :
Center for Biomicrosystems, Korea Inst. of Sci. Technol., Seoul, South Korea
Abstract :
In this paper, we proposed novel detection platform to detect Alzheimer´s amyloid-beta (Aβ) using pre-treated magnetic beads in Electrochemical Impedance Spectroscopy (EIS), for the first time. Without any immobilization on the electrodes of the EIS device, it shows ability to detect a few pg/ml of amyloid-beta oligomers and compared to the result of a conventional ELISA, which allows to simplify the measurement procedure, recycle the device by only changing magnet beads.
Keywords :
biomedical electrodes; diseases; electrochemical impedance spectroscopy; organic compounds; patient diagnosis; Alzheimer amyloid-beta detection platform; EIS device electrode; amyloid-beta oligomer; electrochemical impedance spectroscopy; enzyme-linked immune sorbent assay; magnetic bead; Alzheimer´s disease; Biosensors; Electrodes; Impedance; Magnetic devices; Surface impedance; Surface resistance;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2015 28th IEEE International Conference on
Conference_Location :
Estoril
DOI :
10.1109/MEMSYS.2015.7051028
