Human adipose-derived stem cell fiber for breast reconstruction

This paper describes the construction and differentiation of human adipose-derived stem cell (ADSC) fibers into the adipocyte lineage for breast reconstruction. Human ADSCs were encapsulated into the core region of hydrogel core-shell fibers by the cell fiber technology [1], induced for adipogenic differentiation, and maintained for over 2 months. After adipogenic induction, accumulation of lipid droplets of significant size was observed in the cells, and viability assay showed that most of the cells were alive. These findings suggest the use of ADSC fibers as a promising approach for breast reconstruction.