Title :
Continuous Particle Sorting Utilizing Cascade Squeeze-Jumping Effect Under Microfluidic Configuration
Author :
Lin, Che-Hsin ; Lee, Cheng-Yan ; Fu, Lung-Ming
Author_Institution :
Department of Mechanical and Electro-mechanical Engineering, National Sun Yat-Sen University, Taiwan, ROC
Abstract :
This paper presents a novel method for continuous particle sorting and collection by using of cascade squeeze-jumping effect under microfluidic configuration. Microparticles with different sizes can be successfully separated at different stages of squeezed sheath flows. Separated microparticles then flow into expansion channel blocks to enlarge the distance of the separated flow streams and are collected at different side channels. Only one high voltage is required for generating all the sheath flows for particle separation by applying a series of variable resister to create different electric field levels such that the system is simple and reliable. This study also adopts numerical simulation to analyze and predict the flow fields and stream lines within the microchannel. Experimental results show that the microchip is capable of continuously separating microparticles with the sizes of 5, 10 and 20 μm using the proposed squeeze-jumping effect. The method proposed in this study provides a simple way to continuously separate microparticles/cells with different sizes. More importantly, no delicate control system and fabrication process are required to achieve the sorting and collection.
Keywords :
Biomedical optical imaging; Control systems; Image motion analysis; Magnetic separation; Materials science and technology; Microchannel; Microfluidics; Numerical simulation; Optical sensors; Sorting;
Conference_Titel :
Micro Electro Mechanical Systems, 2006. MEMS 2006 Istanbul. 19th IEEE International Conference on
Conference_Location :
Istanbul, Turkey
Print_ISBN :
0-7803-9475-5
DOI :
10.1109/MEMSYS.2006.1627772