Title :
Chip-Based High-Sensitivity Detection of Multiple Disease Biomarkers
Author :
Goluch, E.D. ; Savka, S.I. ; Georganopoulou, D.G. ; Nam, J.M. ; Shaikh, K.A. ; Ryu, K.S. ; Chiesl, T.N. ; Barron, A.E. ; Mirkin, C.A. ; Liu, C.
Author_Institution :
University of Illinois at Urbana-Champaign, Urbana, IL, U.S.A
Abstract :
Presented in this paper is development of a protocol that employs microarrayed DNA patterns within the channels of an integrated lab-on-a-chip system. The patterned microchannels are used in conjunction with the Bio-Barcode Assay for the rapid multiplexed detection of six DNA disease biomarkers in a single experiment. The successful implementation of the Bio-Barcode Assay in a microfluidic device was further demonstrated by detecting as few as 300 prostate-specific antigen molecules in goat serum samples.
Keywords :
Biomarkers; DNA; Diseases; Glass; Gold; Microfluidics; Nanoparticles; Proteins; Resists; Valves;
Conference_Titel :
Micro Electro Mechanical Systems, 2006. MEMS 2006 Istanbul. 19th IEEE International Conference on
Conference_Location :
Istanbul, Turkey
Print_ISBN :
0-7803-9475-5
DOI :
10.1109/MEMSYS.2006.1627840
