In-vivo Blood Characterization System

Author

Iliev, Blagoy P. ; Pop, Gheorghe A M ; Meijer, Gerard C M

Author_Institution

Fac. of Electr. Eng., Math. & Comput. Sci., Delft Univ. of Technol.

fYear

2006

fDate

24-27 April 2006

Firstpage

1781

Lastpage

1785

Abstract

A blood-impedance measurement system is presented. It is intended for in-vivo analysis of hematocrit and blood viscosity. Using a specially designed central-venous catheter, blood impedance and blood temperature is on line examined. The measurements are performed inside the right atrium, where a strong intracavitary ECG signal is recorded as well. The impedance is measured with sinusoidal signals at five discrete frequencies in the range from 20 kHz to 1.2 MHz. The temperature is measured with a tiny thermistor incorporated in the catheter´s tip. From the various blood-impedance components, the measurement system derives plasma resistance, cell membrane capacitance and cell interior resistance. Proper catheter positioning and processing of the measured impedance components are guided by the ECG signal, sensed with the same impedance sensor. A wide variety of biocompatibility issues has thoroughly been identified and related problems have been solved

Keywords

biomedical measurement; blood; catheters; electric impedance measurement; electrocardiography; temperature measurement; thermistors; viscosity; 0.02 to 1.2 MHz; ECG signal; biocompatibility; blood characterization; blood impedance measurement; blood temperature measurement; blood viscosity; cell interior resistance; cell membrane capacitance; central-venous catheter; hematocrit analysis; impedance sensor; plasma resistance; thermistor; Blood; Catheters; Cells (biology); Electrical resistance measurement; Electrocardiography; Immune system; Impedance measurement; Plasma temperature; Temperature measurement; Viscosity; Blood impedance; Hematocrit; In-vivo; Viscosity;

fLanguage

English

Publisher

ieee

Conference_Titel

Instrumentation and Measurement Technology Conference, 2006. IMTC 2006. Proceedings of the IEEE

Conference_Location

Sorrento

ISSN

1091-5281

Print_ISBN

0-7803-9359-7

Electronic_ISBN

1091-5281

Type

conf

DOI

10.1109/IMTC.2006.328249

Filename

4124657