An implantable 5mW/channel dual-wavelength optogenetic stimulator for therapeutic neuromodulation research

Author

Paralikar, Kunal ; Peng Cong ; Santa, Wes ; Dinsmoor, David ; Hocken, Bob ; Munns, G. ; Giftakis, J. ; Denison, Tim

Author_Institution

Medtronic Technol., Minneapolis, MN, USA

fYear

2010

fDate

7-11 Feb. 2010

Firstpage

238

Lastpage

239

Abstract

This paper describes an implantable system prototype capable of delivering optical intensities and modulation patterns suitable to therapeutically modulate neural networks. It leverages the emerging "optogenetic" interface paradigm for exciting or inhibiting neural activity with the advantages of genetically targeted stimulation and enhanced MRI/EMI compatibility.

Keywords

bioelectric phenomena; biomedical MRI; biomolecular effects of radiation; cellular biophysics; electromagnetic interference; neural nets; neurophysiology; patient treatment; prosthetics; proteins; MRI-EMI compatibility; genetically targeted stimulation; implantable dual wavelength optogenetic stimulator; neural network modulation; optical intensity; optical modulation patterns; optogenetic interface paradigm; therapeutic neuromodulation; Electrodes; Light emitting diodes; Medical treatment; Optical scattering; Optical sensors; Optical transmitters; Photonic integrated circuits; Power system management; Stimulated emission; Telemetry;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Circuits Conference Digest of Technical Papers (ISSCC), 2010 IEEE International

Conference_Location

San Francisco, CA

ISSN

0193-6530

Print_ISBN

978-1-4244-6033-5

Type

conf

DOI

10.1109/ISSCC.2010.5433938

Filename

5433938