DocumentCode
1896537
Title
Potentiometric detection of protein interactions with peptide aptamers
Author
Estrela, Pedro ; Paul, Debjani ; Migliorato, Piero ; Ferrigno, Paul Ko ; Wang, Ling ; Huq, Ejaz
Author_Institution
Dept. of Eng., Univ. of Cambridge, Cambridge
fYear
2008
fDate
26-29 Oct. 2008
Firstpage
646
Lastpage
649
Abstract
Label-free electrical detection of protein interactions has been achieved by direct measurement of variations in open circuit potential using an accurate differential voltage measurement as well as field-effect transistors. Our model system involves a panel of peptide aptamers that recognise specific protein partners of the cyclin-dependent kinase family, which are relevant to cancer research applications.
Keywords
bioelectric phenomena; biosensors; field effect transistors; molecular biophysics; potentiometers; proteins; Label-free electrical detection; differential voltage measurement; field-effect transistors; open circuit potential; peptide aptamers; potentiometric detection; protein interactions; Cancer; Charge measurement; Circuits; Current measurement; Electrical resistance measurement; FETs; Instruments; Peptides; Protein engineering; Voltage measurement;
fLanguage
English
Publisher
ieee
Conference_Titel
Sensors, 2008 IEEE
Conference_Location
Lecce
ISSN
1930-0395
Print_ISBN
978-1-4244-2580-8
Electronic_ISBN
1930-0395
Type
conf
DOI
10.1109/ICSENS.2008.4716524
Filename
4716524
Link To Document