Title :
Robustness analysis of biomolecular networks
Author :
Waldherr, Steffen
Author_Institution :
Inst. for Autom. Eng., Otto-von-Guericke-Univ., Magdeburg, Germany
Abstract :
Robustness is a widely studied property of biomolecular networks, and control engineers are in a good position to make significant contributions here. This tutorial defines common robustness analysis problems for biomolecular networks, presents computational methods to perform the analysis, and shows by means of examples what can be learned about a network from the analysis results. The focus is on deterministic methods applied to ordinary differential equation models of biomolecular networks.
Keywords :
biology; deterministic algorithms; differential equations; molecular biophysics; biomolecular networks; computational methods; deterministic methods; ordinary differential equation models; robustness analysis problems; Bifurcation; Biological system modeling; Jacobian matrices; Mathematical model; Robustness; Steady-state;
Conference_Titel :
Control Conference (ECC), 2014 European
Conference_Location :
Strasbourg
Print_ISBN :
978-3-9524269-1-3
DOI :
10.1109/ECC.2014.6862637