Title :
Viral quasispecies assembly from paired-end reads
Author :
Topfer, Armin ; Beerenwinkel, Niko
Author_Institution :
Dept. of Biosyst. Sci. & Eng., ETH Zurich, Basel, Switzerland
Abstract :
Viruses can display high intra-patient genetic diversity. A single infected individual hosts billions of virus particles that can be summarized as a set of genetically different strains, called haplotypes, with their respective frequencies. The haplotype distribution, also known as a viral quasispecies, is a key determinent of virulence, pathogenesis, and treatment outcome.
Keywords :
genetics; genomics; microorganisms; self-assembly; genetically different strains; haplotype distribution; intrapatient genetic diversity; paired-end reads; pathogenesis; viral quasispecies assembly; virulence; Assembly; Bioinformatics; Electronic mail; Genetics; Next generation networking; Sequential analysis; Viruses (medical); Haplotype reconstruction; next-generation sequencing; paired-end reads; viral quasispecies assembly;
Conference_Titel :
Computational Advances in Bio and Medical Sciences (ICCABS), 2014 IEEE 4th International Conference on
Conference_Location :
Miami, FL
Print_ISBN :
978-1-4799-5786-6
DOI :
10.1109/ICCABS.2014.6863931
