Title :
Detection of genetic relatedness between viral samples using EM-based clustering of next-generation sequencing data
Author :
Skums, Pavel ; Artyomenko, Alexander ; Glebova, Olga ; Zelikovsky, Alexander ; Campo, David S. ; Dimitrova, Zoya ; Khudyakov, Yury
Author_Institution :
Centers of Disease Control & Prevention, Atlanta, GA, USA
Abstract :
We present a novel general tool for highly sensitive detection of genetic relatedness between highly heterogeneous viral samples based on the clustering of next-generation sequencing data. The tool may be used for detection of viral transmissions and outbreaks and for laboratory quality control.
Keywords :
diseases; epidemics; genetics; genomics; microorganisms; EM-based clustering; genetic relatedness detection; heterogeneous viral samples; laboratory quality control; next-generation sequencing data; viral outbreak detection; viral transmission detection; Electronic mail; Genetics; Next generation networking; Quality control; Sequential analysis; Sociology; Statistics;
Conference_Titel :
Computational Advances in Bio and Medical Sciences (ICCABS), 2014 IEEE 4th International Conference on
Conference_Location :
Miami, FL
Print_ISBN :
978-1-4799-5786-6
DOI :
10.1109/ICCABS.2014.6863938
