Title :
Delivery of Drugs and Finite Speed Diffusion and Response to Pulse Decay
Author :
Sharma, Kal Renganathan
Abstract :
Controlled relased technology can be more effective in delivering drungs compared with the periodic doses that is currently in vogue. Drug delivery stytems are often dominated by the process of diffusion. The Fick´s law of mass diffusion has limitations in the short time regime which is of interest in the drug delivery systems. A damped wave non-Fick diffusion and relaxation equation can be derived from the free electron theory by accounting for the acceleration of mass flow effects. The governing equation that results from this equation is solved for the pulse response to the drug by the method of Laplace transorms. A modified Bessel composite function of the first kind and zeroth order and a decaying exponential in time results as the exact solution. The concentration profile exhibits some symmetry and possess saddle points.
Keywords :
Chemical technology; Drug delivery; Extracellular; Implants; Laplace equations; Medical treatment; Pharmaceutical technology; Physiology; Plasma measurements; Polymers;
Conference_Titel :
Bioengineering Conference, 2006. Proceedings of the IEEE 32nd Annual Northeast
Conference_Location :
Easton, PA, USA
Print_ISBN :
0-7803-9563-8
DOI :
10.1109/NEBC.2006.1629814