High-throughput size determination of nearly spherical gold nanoparticles

This paper demonstrates a wide-field interferometric imaging technique for determining the size of nearly spherical gold particles. Investigation of interferometric response as a function of polarization angle of illumination reveals the absolute dimensions and lateral orientation angle of the nanoparticles immobilized on a precisely designed reflective layered substrate. We demonstrate the sensitivity, precision and multiplexing capability of the method by studying a solution of gold nanoparticles with 45nm in diameter. The technique is promising for applications that require sensitive morphology characterization of nearly spherical nanoparticles.