Title :
Inserting the Effects of Ion Channels in Mean Field Models: Application to generation of anesthetic slow waves
Author :
Ardekani, Behnam Molaee ; Senhadji, Lotfi ; Shamsollahi, Mohammad Bagher
Author_Institution :
LTSI INSERM, Rennes1 Univ., Rennes
Abstract :
In this paper, effects of general anesthesia on the electroencephalogram (EEG) have been modeled with an enhanced physiological mean field theory of electrocortical activity. Enhancement is done by inserting two intrinsic ion channels (IKNa and I AR) in Lilly´s mean field model. In addition to excitatory and inhibitory synapses, intrinsic ion channels can generate or manipulate the brain rhythms. IKNa and IAR can produce slow brain rhythms (delta band frequency) in deep levels of anesthesia. We represent the activities of each mentioned ion channels by cascading a nonlinear function and a first order low pass filter. Linearized and numerical solutions of the modified model show that the power spectrum densities of simulated EEG signals are more closed to reality
Keywords :
electroencephalography; low-pass filters; medical signal processing; neurophysiology; nonlinear functions; EEG; Lilly mean field model; anesthetic slow wave generation; electrocortical activity; electroencephalogram; first order low pass filter; general anesthesia; ion channel effects; nonlinear function; physiological mean field theory; power spectrum density; Anesthesia; Anesthetic drugs; Brain modeling; Diseases; Electroencephalography; Frequency; Low pass filters; Neurons; Rhythm; Surgery; Anesthesia; Delta Waves; Ion Channels; Mean Field Theory;
Conference_Titel :
Computer as a Tool, 2005. EUROCON 2005.The International Conference on
Conference_Location :
Belgrade
Print_ISBN :
1-4244-0049-X
DOI :
10.1109/EURCON.2005.1629941