A method for comparison of optimization algorithms used in compartmental modelling

Author

Moulin, M.L. ; Frouin, F. ; Baazin, J.P. ; Benali, H. ; Manil, L. ; Paola, R. Di

Author_Institution

INSERM, Inst. Gustave-Roussy, Villejuif, France

fYear

1992

fDate

25-31 Oct 1992

Firstpage

1141

Abstract

A protocol is proposed to compare the performance of five minimization algorithms used in compartmental modeling. Kinetics are computed from the model being tested, and noise added to them with different signal-to-noise ratios. These noisy curves undergo compartmental analysis in the case of good a priori and poor a priori knowledge of the parameters to be estimated. The protocol makes it possible to guide the choice of an algorithm and to test numerical identifiability of a model. It also emphasizes the unreliability of the conventional confidence intervals computation

Keywords

computerised tomography; modelling; optimisation; radioisotope scanning and imaging; comparison; compartmental analysis; compartmental modelling; confidence intervals computation; minimization algorithms; noisy curves; optimization algorithms; performance; signal-to-noise ratios; Algorithm design and analysis; Iterative algorithms; Kinetic theory; Least squares approximation; Minimization methods; Optimization methods; Protocols; Sensitivity analysis; Software algorithms; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Nuclear Science Symposium and Medical Imaging Conference, 1992., Conference Record of the 1992 IEEE

Conference_Location

Orlando, FL

Print_ISBN

0-7803-0884-0

Type

conf

DOI

10.1109/NSSMIC.1992.301055

Filename

301055