Optical fiber nanotips as carriers for molecular beacon-based biosensors

Author

Barucci, A. ; Giannetti, A. ; Cosi, F. ; Tombelli, S. ; Trono, C. ; Righini, Giancarlo C. ; Baldini, F. ; Pelli, Stefano

Author_Institution

Ist. di Fis. Appl. "Nello Carrara", Sesto Fiorentino, Italy

fYear

2013

fDate

12-16 May 2013

Firstpage

1

Lastpage

1

Abstract

Here we present some preliminary results concerning the use of a fibre optical nanotip with a molecular beacon (MB) immobilized for cancer theranostics. The solid support chosen as substrate for the immobilization of the MB was a tip of an optical fibre tapered at nanoscale size, intended to be used in the future to probe directly inside the cytoplasm of living cells. The nanotip was fabricated by chemical etching, starting from 500 micron - diameter multimode optical fibre down to 100 nm at the tip. Next, the fibre tips were silanized, and MB attached via covalent-binding procedure.

Keywords

biosensors; cancer; cellular biophysics; etching; nanobiotechnology; nanofabrication; nanophotonics; optical fabrication; optical fibres; cancer theranostics; chemical etching; covalent-binding procedure; cytoplasm; living cells; molecular beacon-based biosensors; multimode optical fibre; nanoscale size; optical fiber nanotips; solid support; Cancer; Fluorescence; Nanobioscience; Optical buffering; Optical fibers; Optical sensors; Proteins;

fLanguage

English

Publisher

ieee

Conference_Titel

Lasers and Electro-Optics Europe (CLEO EUROPE/IQEC), 2013 Conference on and International Quantum Electronics Conference

Conference_Location

Munich

Print_ISBN

978-1-4799-0593-5

Type

conf

DOI

10.1109/CLEOE-IQEC.2013.6801458

Filename

6801458