DocumentCode :
1933321
Title :
Combining Voxel-based Morphometry with Artifical Neural Network Theory in the Application Research of Diagnosing Alzheimer´s Disease
Author :
Huang, Chengzhong ; Yan, Bin ; Jiang, Hua ; Wang, Dahui
Author_Institution :
Inf. Sci. & Technol. Inst., Zhengzhou
Volume :
1
fYear :
2008
fDate :
27-30 May 2008
Firstpage :
250
Lastpage :
254
Abstract :
The purpose of our study was to explore the automatic method of detecting the gray matter loss of Alzheimer´s disease (AD) patients with magnetic resonance imaging (MRI). In this paper, we tried to combine voxel-based morphometry(VBM) with Artificial Neural Network(ANN) in diagnosing Alzheimer´s disease(AD). Firstly, the features were obtained by VBM method, and then principal component analysis(PCA) was used for feature dimensionality reduction to improve its efficiency. Then, a single three-layer, feed-forward ANN with a back-propagation algorithm was used as a classifier. Finally, the performance of the neural network was evaluated by validation protocol. By taking 20 features into account, which were obtained by VBM. The overall predictive capability of Back-Propagation Neural Network in differentiating AD from normal controls reached 100%. The network kept the accuracy of classification consistently. Also, the result will be slightly better with the process of PCA. In conclusion, the results of this study confirmed that the method of combination VBM with ANN could be used in the early diagnosis of AD.
Keywords :
biomedical MRI; brain; medical computing; neural nets; principal component analysis; Alzheimer disease diagnostics; MRI; artifical neural network theory; back propagation neural network; feature dimensionality reduction; gray matter loss; magnetic resonance imaging; principal component analysis; voxel-based morphometry; Aging; Alzheimer´s disease; Artificial neural networks; Atrophy; Biological neural networks; Biomedical measurements; Dementia; Magnetic resonance imaging; Neural networks; Principal component analysis; Alzheimer´s disease(AD); Artifical Neural Network; PCA; magnetic reso-nance imaging; voxel-based morphometry;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
BioMedical Engineering and Informatics, 2008. BMEI 2008. International Conference on
Conference_Location :
Sanya
Print_ISBN :
978-0-7695-3118-2
Type :
conf
DOI :
10.1109/BMEI.2008.245
Filename :
4548671
Link To Document :
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