DocumentCode
1934161
Title
A Method to Correct Systematic Bias in Affymetrix SNP Arrays
Author
Wan, Lin ; Fu, Wenjiang J. ; Deng, Minghua ; Qian, Minping
Author_Institution
Sch. of Math. Sci., Peking Univ., Beijing
Volume
1
fYear
2008
fDate
27-30 May 2008
Firstpage
442
Lastpage
446
Abstract
Affymetrix SNP arrays are important tools and widely used for both genotyping and copy number estimation. We found previously that systematic bias exists in Affymetrix SNP arrays and leads to loss of accuracy in copy number estimations. In this paper, we showed that systematic bias within SNP arrays is multiplicative effect (or additive effects in the log scale) to probe intensities. Based on this observation, a method was introduced to correct the systematic bias within SNP arrays.
Keywords
genetic algorithms; medical image processing; affymetrix SNP arrays; copy number estimation; genotyping; multiplicative effect; systematic bias; Additives; Bioinformatics; Biomedical engineering; Biomedical informatics; DNA; Genomics; Humans; Probes; Prototypes; Sequences; Affymetrix SNP arrays; copy number estimation; systematic bias;
fLanguage
English
Publisher
ieee
Conference_Titel
BioMedical Engineering and Informatics, 2008. BMEI 2008. International Conference on
Conference_Location
Sanya
Print_ISBN
978-0-7695-3118-2
Type
conf
DOI
10.1109/BMEI.2008.41
Filename
4548708
Link To Document