Title :
A Method to Correct Systematic Bias in Affymetrix SNP Arrays
Author :
Wan, Lin ; Fu, Wenjiang J. ; Deng, Minghua ; Qian, Minping
Author_Institution :
Sch. of Math. Sci., Peking Univ., Beijing
Abstract :
Affymetrix SNP arrays are important tools and widely used for both genotyping and copy number estimation. We found previously that systematic bias exists in Affymetrix SNP arrays and leads to loss of accuracy in copy number estimations. In this paper, we showed that systematic bias within SNP arrays is multiplicative effect (or additive effects in the log scale) to probe intensities. Based on this observation, a method was introduced to correct the systematic bias within SNP arrays.
Keywords :
genetic algorithms; medical image processing; affymetrix SNP arrays; copy number estimation; genotyping; multiplicative effect; systematic bias; Additives; Bioinformatics; Biomedical engineering; Biomedical informatics; DNA; Genomics; Humans; Probes; Prototypes; Sequences; Affymetrix SNP arrays; copy number estimation; systematic bias;
Conference_Titel :
BioMedical Engineering and Informatics, 2008. BMEI 2008. International Conference on
Conference_Location :
Sanya
Print_ISBN :
978-0-7695-3118-2
DOI :
10.1109/BMEI.2008.41
