Author_Institution :
Lincoln Lab., Massachusetts Inst. of Technol., Lexington, MA
Abstract :
We have developed a new type of sensor, dubbed CANARY (Cellular Analysis and Notification of Antigen Risks and Yields), that is able to identify pathogens in a very rapid, sensitive, and specific manner. The sensor uses genetically engineered white blood cells that emit light within seconds after being exposed to particular pathogens of interest. We have produced cells to identify a variety of bacteria and viruses, including anthrax, smallpox, plague, E. coli, and foot-and-mouth virus, and we have shown that the cells can detect fewer than 50 pathogen particles. Because of its speed and sensitivity, CANARY has the potential to revolutionize biowarfare defense, medical diagnostics, food- and water-quality monitoring, and other applications
Keywords :
biosensors; blood; cellular biophysics; diseases; microorganisms; E. coli; anthrax; antigen risks notification; bacteria; biowarfare defense; canary sensor; dubbed cellular analysis; food-quality monitoring; foot-and-mouth virus; genetically engineered white blood cells; medical diagnostics; pathogen identification; plague; smallpox; water-quality monitoring; Biomedical monitoring; Genetic engineering; Laboratories; Medical diagnosis; Microorganisms; Pathogens; Risk analysis; Viruses (medical); White blood cells;
