DocumentCode :
1943344
Title :
Organization of hippocampal place cells by enthorinal cortex grid cells. A functional role for the phase precession mechanism.
Author :
Molter, Colin ; Yamaguchi, Yoko
Author_Institution :
RIKEN Brain Sci. Inst., Saitama
fYear :
2007
fDate :
12-17 Aug. 2007
Firstpage :
944
Lastpage :
949
Abstract :
Thirty years ago, hippocampal cells firing at selective location in the environment were discovered, with a major impact in our understanding of memory formation. Recently, "grid cells", firing when the rat is located at any of the vertices of grid fields covering the environment, have been discovered in the medial enthorinal cortex. These cells are supposed to be responsible for the organization of hippocampal place cells. Computational models have already validated this theory. However, multiple grid scales were assumed which does not follow anatomical evidences. We propose here a model relying on the phase precession dynamics: when the rat crosses a field of a particular grid cell, its spikes shift to earlier phases of the theta rhythm. We demonstrate how this dynamics can reliably explain the organization of place cells without relying on multiple grid scales. Moreover, hippocampal place cell phase precession results from grid cell phase precession.
Keywords :
cellular biophysics; neurophysiology; enthorinal cortex grid cell; hippocampal place cell; multiple grid scale; phase precession mechanism; Brain modeling; Computational modeling; Encoding; Fires; Hippocampus; Navigation; Neural networks; Neurons; Rhythm; Rodents;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Neural Networks, 2007. IJCNN 2007. International Joint Conference on
Conference_Location :
Orlando, FL
ISSN :
1098-7576
Print_ISBN :
978-1-4244-1379-9
Electronic_ISBN :
1098-7576
Type :
conf
DOI :
10.1109/IJCNN.2007.4371085
Filename :
4371085
Link To Document :
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