Title :
Nerve fiber stimulation threshold for multiphase stimuli
Author :
Beecroft, S.I. ; Alkhateeb, A. ; Gaumond, R.P.
Author_Institution :
Bioeng. Program, Pennsylvania State Univ., University Park, PA, USA
Abstract :
The authors determined the strength-duration curves for stimulus pulse waveforms of one, two, or three rectangular phases of alternating polarity. Stimuli represented the induced transmembrane current density for a voltage-clamped unmyelinated axon. For any pulse length, the one-phase pulse always required the least current density to cause an action potential, while the two-phase pulse always required the most. For short pulse lengths (<τm, time constant for sodium gate activation at resting potential), the three-phase pulse curve approached that of the one-phase pulse; for long pulse lengths (>τmem, time constant of the resting membrane), the three-phase pulse curve approached that of the two-phase pulse
Keywords :
bioelectric phenomena; neurophysiology; physiological models; Na; action potential; alternating polarity; induced transmembrane current density; multiphase stimuli; nerve fiber stimulation threshold; rectangular phase; resting membrane time constant; resting potential; sodium gate activation; stimulus pulse waveforms; strength-duration curves; voltage-clamped unmyelinated axon; Biomedical engineering; Biomembranes; Coils; Current density; Equations; Magnetic flux; Nerve fibers; Pulse circuits; RLC circuits; Voltage;
Conference_Titel :
Bioengineering Conference, 1994., Proceedings of the 1994 20th Annual Northeast
Conference_Location :
Springfield, MA
Print_ISBN :
0-7803-1930-3
DOI :
10.1109/NEBC.1994.305174
