Modeling and computer simulation of the effect of degree of autoregulation on arteriovenous malformation occlusion

A new model and computer simulation of an intracranial cerebral arteriovenous malformation (AVM) is developed based on an existing model which doesn´t include a variable degree of cerebral autoregulation that occurs in AVM patients. By modeling and computer simulation, the authors investigate the relationship between the resultant oedema or haemorrhage after AVM resection and the degree of cerebral autoregulation. The simulation results suggest that the resultant problems following AVM occlusion can be very severe for patients without normal functional autoregulation