Parameter addition in interaction of glucose and insulin for type 1 diabetes

Recently, in silico testing which is managed via computer simulation, is preferably performed on Diabetes patients rather than to be evaluated directly on their body due to the benefit of patient safety and accelerated progress obtained from the convenient testing. However, it is still difficult to have an accurate and efficient Diabetes therapy through this simulation method. Therefore, continuous investigation and research are necessary so as to enhance a reliable Diabetes treatment in future. In this work, we propose an improved Diabetic model that emphasizes on detailed inter-relation of glucose and insulin reaction referring to the Hovorka model. This study was undertaken to improve Diabetes treatment in particular for Type 1 patient by ensuring all parameters involved in glucose-insulin interaction do include in the Diabetic model equations. The equations in Hovorka model have been modified in glucose subsystem, plasma insulin concentration and insulin subsystem while the other equations remain unchanged. As a result, we managed to have a good correlation on interactions between the parameters in glucose-insulin intervention. We hope this correlation can contribute to the field of Diabetes therapy enhancement so as to help the patients to achieve a near normal blood glucose level and manage to control their healthy life style.