Title :
Effect of energy of square-wave pulse on transdermal delivery of tetracaine
Author :
Jiali, Bao ; Wenquan, Liang ; Qiaohong, Hu
Author_Institution :
Physiol. & Pathophysiology Inst., Zhejiang Univ., Hangzhou, China
Abstract :
Transdermal drug delivery (TDD) by electroporation is an attractive novel method of facilitating the transport of compounds across skin in which a short electrical pulse is applied to the skin, forcing the creation of a reversible transient aqueous pore to enhance the drug´s transdermal permeability. Most prior researches are difficult to put into the practical use, such as stimulation for user and designing electroporative apparatus for TDD, due to a pulse with high intensity. In this paper, the effect of electroporative energy on the permeable fluxes of tetracaine (TC) to pass through the skin is studied to explore a way of using an electroporative technique with low voltage. We applied a 130 V square pulse to SD male rat´s skin on the abdomen; the permeable flux of TC increased 5.1 times more than the passive transport.
Keywords :
biodiffusion; bioelectric phenomena; drug delivery systems; permeability; skin; 130 V; SD male rat skin; abdomen; drug transdermal permeability; electroporation; electroporative energy; low voltage; passive transport; permeable fluxes; reversible transient aqueous pore; short electrical pulse; square pulse; square-wave pulse energy effect; tetracaine transdermal delivery; transdermal drug delivery; Biochemistry; Chemical technology; Degradation; Drug delivery; Educational institutions; Permeability; Pharmaceutical technology; Predictive models; Proteins; Skin;
Conference_Titel :
Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE
Print_ISBN :
0-7803-7211-5
DOI :
10.1109/IEMBS.2001.1017467