DocumentCode :
1952269
Title :
Three-dimensional high-frequency spectral and envelope quantification of excised human lymph nodes
Author :
Mamou, Jonathan ; Coron, Alain ; Oelze, Michael L. ; Saegusa-Beecroft, Emi ; Hata, Masaki ; Mach, Junji ; Yanagihara, Eugene ; Laugier, Pascal ; Feleppa, Ernest J.
Author_Institution :
Frederic L. Lizzi Center for Biomed. Eng., Riverside Res. Inst., New York, NY, USA
fYear :
2010
fDate :
11-14 Oct. 2010
Firstpage :
604
Lastpage :
607
Abstract :
Quantitative imaging methods using high-frequency ultrasound (HFU, >;20 MHz) offer a means of characterizing biological tissue at the microscopic level. In this study, three-dimensional (3D) quantitative-ultrasound (QUS) methods were developed to detect metastases in freshly-dissected lymph nodes of cancer patients. 3D ultrasound radio-frequency data were acquired using a 26-MHz center-frequency transducer, and each node was inked prior to tissue fixation to recover orientation after sectioning for 3D histological evaluation. Backscattered echo signals were processed using 3D cylindrical regions-of-interest (ROIs) to yield eight QUS estimates associated with tissue microstructure. The first four QUS estimates (i.e., effective scatterer size, acoustic concentration, intercept, and slope) were estimated from a normalized backscattered spectrum, and the other four QUS estimates were obtained by parameterizing the envelope statistics of the ROIs using Nakagami and homodyned-K models. These QUS methods were applied to 145 lymph nodes from 95 colorectal and gastric cancer patients. The ability of these eight QUS estimates to classify lymph nodes and detect cancer was evaluated using ROC curves. An area under the ROC curve of 0.971 with specificity and sensitivity of 91% (using a leave-one-out procedure) were obtained by combining effective scatterer size and one envelope parameter based on the homodyned-K distribution. Therefore, these advanced 3D QUS methods potentially can be valuable for detecting small metastatic foci in dissected lymph nodes.
Keywords :
biomedical transducers; biomedical ultrasonics; cancer; medical image processing; sensitivity analysis; tumours; ultrasonic transducers; 3D cylindrical regions-of-interest; 3D histological evaluation; Nakagami model; ROC curve; acoustic concentration; backscattered echo signals; biological tissue; colorectal cancer; effective scatterer size; envelope quantification; excised human lymph nodes; frequency 26 MHz; gastric cancer; high frequency ultrasound; homodyned-K model; metastases; metastatic foci; normalized backscattered spectrum; quantitative imaging methods; sensitivity; specificity; three dimensional quantitative ultrasound methods; three-dimensional high-frequency spectral quantification; tissue fixation; tissue microstructure; transducer; Acoustics; Cancer; Lymph nodes; Nakagami distribution; Sensitivity; Three dimensional displays; Ultrasonic imaging; high-frequency ultrasound; lymph node; quantitative ultrasound;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium (IUS), 2010 IEEE
Conference_Location :
San Diego, CA
ISSN :
1948-5719
Print_ISBN :
978-1-4577-0382-9
Type :
conf
DOI :
10.1109/ULTSYM.2010.5935488
Filename :
5935488
Link To Document :
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