Title :
Ultrasound and photoacoustic image-guided photothermal therapy using silica-coated gold nanorods: In-vivo study
Author :
Kim, Seungsoo ; Chen, Yun-Sheng ; Luke, Geoffrey P. ; Mehrmohammadi, Mohammad ; Cook, Jason R. ; Emelianov, Stanislav Y.
Author_Institution :
Dept. of Biomed. Eng., Univ. of Texas at Austin, Austin, TX, USA
Abstract :
In nanoparticle mediated photothermal therapy, confirmation of nanoparticle delivery/deposition in a tumor before therapy and temperature monitoring during therapy are needed to optimize therapeutic outcomes. In this paper, we demonstrate that ultrasound and photoacoustic imaging techniques can plan and guide photothermal cancer therapy, using an in-vivo mouse model of subcutaneous cancer intravenously administrated with silica-coated gold nanorods.
Keywords :
biomedical ultrasonics; cancer; gold; nanomedicine; nanoparticles; nanorods; photoacoustic effect; physiological models; radiation therapy; silicon compounds; tumours; SiO2-Au; cancer therapy; nanoparticle; photoacoustic image-guided photothermal therapy; silica-coated gold nanorods; tumor; ultrasound image-guided photothermal therapy; Cancer; Imaging; Medical treatment; Mice; Nanoparticles; Tumors; Ultrasonic imaging; Nanoparticles; photoacoustics; photothermal therapy; spectroscopy; thermal imaging;
Conference_Titel :
Ultrasonics Symposium (IUS), 2010 IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4577-0382-9
DOI :
10.1109/ULTSYM.2010.5935601
