Ultrasound and photoacoustic image-guided photothermal therapy using silica-coated gold nanorods: In-vivo study

Author

Kim, Seungsoo ; Chen, Yun-Sheng ; Luke, Geoffrey P. ; Mehrmohammadi, Mohammad ; Cook, Jason R. ; Emelianov, Stanislav Y.

Author_Institution

Dept. of Biomed. Eng., Univ. of Texas at Austin, Austin, TX, USA

fYear

2010

fDate

11-14 Oct. 2010

Firstpage

233

Lastpage

236

Abstract

In nanoparticle mediated photothermal therapy, confirmation of nanoparticle delivery/deposition in a tumor before therapy and temperature monitoring during therapy are needed to optimize therapeutic outcomes. In this paper, we demonstrate that ultrasound and photoacoustic imaging techniques can plan and guide photothermal cancer therapy, using an in-vivo mouse model of subcutaneous cancer intravenously administrated with silica-coated gold nanorods.

Keywords

biomedical ultrasonics; cancer; gold; nanomedicine; nanoparticles; nanorods; photoacoustic effect; physiological models; radiation therapy; silicon compounds; tumours; SiO₂-Au; cancer therapy; nanoparticle; photoacoustic image-guided photothermal therapy; silica-coated gold nanorods; tumor; ultrasound image-guided photothermal therapy; Cancer; Imaging; Medical treatment; Mice; Nanoparticles; Tumors; Ultrasonic imaging; Nanoparticles; photoacoustics; photothermal therapy; spectroscopy; thermal imaging;

fLanguage

English

Publisher

ieee

Conference_Titel

Ultrasonics Symposium (IUS), 2010 IEEE

Conference_Location

San Diego, CA

ISSN

1948-5719

Print_ISBN

978-1-4577-0382-9

Type

conf

DOI

10.1109/ULTSYM.2010.5935601

Filename

5935601