Title :
Viscoelastic measurements on perfused and non-perfused swine renal cortex in vivo
Author :
Amador, Carolina ; Urban, Matthew W. ; Kinnick, Randall ; Chen, Shigao ; Greenleaf, James F.
Author_Institution :
Dept. of Physiol. & Biomed. Eng., Mayo Clinic Coll. of Med., Rochester, MN, USA
Abstract :
Renal fibrosis threatens kidney viability and fibrosis has been associated with altered tissue structure affecting the biomechanical properties of the kidney, such as elasticity and viscosity. Although there are limited studies regarding viscoelastic properties of renal tissue, an in vivo renal MRE study suggests that shear elasticity changes as a result of hemodynamic variables. A newly emerging method called Shearwave Dispersion Ultrasound Vibrometry (SDUV) offers a tool to determine renal elasticity and viscosity in vivo. SDUV quantifies both elasticity and viscosity by evaluating dispersion of shear wave propagation speed versus its frequency. The purpose of this study is to evaluate the feasibility of SDUV for in vivo measurements of elasticity and viscosity on normal swine kidney consequent to acute changes in renal hemodynamics.
Keywords :
biological tissues; biomechanics; biomedical measurement; biomedical ultrasonics; diseases; elasticity; haemodynamics; kidney; ultrasonic measurement; vibration measurement; viscoelasticity; viscosity; biomechanical properties; elasticity; hemodynamics; kidney viability; renal fibrosis; shear elasticity; shear wave propagation speed; shearwave dispersion ultrasound vibrometry; swine renal cortex; viscoelastic measurement; viscosity; Animals; Dispersion; Elasticity; In vivo; Kidney; Ultrasonic imaging; Viscosity; Renal cortex; elasticity; viscosity;
Conference_Titel :
Ultrasonics Symposium (IUS), 2010 IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4577-0382-9
DOI :
10.1109/ULTSYM.2010.5935672
