Nafion coated enzyme free glucose micro-biosensors for anti-fouling of protein

Author

Lee, Yi Jae ; Kim, Jung Doo ; Park, Jae Yeong

Author_Institution

Dept. of Electron. Eng., Kwangwoon Univ., Seoul

fYear

2009

fDate

5-8 Jan. 2009

Firstpage

335

Lastpage

338

Abstract

Enzyme free glucose micro-biosensors with nanoporous platinum (Pt) electrode were fully packaged with biocompatible Nafion membrane and characterized in bio-fluidic solutions. Three different packaging methods which were a dip coating, spin-casting, and chemical bonding were applied, characterized, and compared to find an optimal one for anti-fouling of protein in bio-fluidic solution. In human plasma and whole blood solutions, the packaged sensors with chemically bonded Nafion film showed relatively large current response and high sensitivity of 0.32 muA / mMmiddotcm² which was the highest in the reported glucose sensors.

Keywords

biochemistry; biomembranes; biosensors; blood; bonds (chemical); dip coating; electrodes; electronics packaging; enzymes; microsensors; molecular biophysics; nanoporous materials; platinum; polymer films; proteins; spin coating; Pt; biocompatible Nafion membrane; biofluidic solution; blood solution; chemical bonding; chemically bonded Nafion film; dip coating; enzyme free glucose microbiosensor; glucose sensor; human plasma; nanoporous platinum electrode; packaged sensor; packaging methods; protein antifouling; spin-casting; Biochemistry; Biosensors; Bonding; Chemical and biological sensors; Electrodes; Nanoporous materials; Packaging; Platinum; Proteins; Sugar; Anti-fouling; Enzyme free; Glucose; Micro-biosensor; Nafion; Nanoporous platinum;

fLanguage

English

Publisher

ieee

Conference_Titel

Nano/Micro Engineered and Molecular Systems, 2009. NEMS 2009. 4th IEEE International Conference on

Conference_Location

Shenzhen

Print_ISBN

978-1-4244-4629-2

Electronic_ISBN

978-1-4244-4630-8

Type

conf

DOI

10.1109/NEMS.2009.5068590

Filename

5068590