Title :
Finite Element Modeling of Cell Exposed To Harmonic and Transient Electric Fields
Author :
Meny, I. ; Burais, N. ; Buret, F. ; Nicolas, L.
Author_Institution :
CEGELY, Ecole Centrale de Lyon, Ecully
Abstract :
The transmembrane potential (TMP) of a cell exposed to harmonic or transient electric fields is the main parameter for a successful permeabilization of a cell. Obviously, TMP can be computed with a finite element method, but the high contrast between sizes and electromagnetic properties of the cytoplasm, the membrane, and the extra-cellular medium leads sometimes to inaccurate numerical results. Influence of various parameters on the accuracy is studied. Finally, optimal electric transient waveforms are proposed for various shapes and sizes of cells
Keywords :
biological effects of fields; biomembranes; cellular biophysics; electric fields; finite element analysis; harmonics; cytoplasm; electromagnetic properties; extra-cellular medium; finite element modeling; harmonic; membrane; permeabilization; transient electric fields; transmembrane potential; Biomembranes; Conductivity; Electromagnetic transients; Equations; Extracellular; Finite element methods; Frequency; Shape; Solid modeling; Voltage;
Conference_Titel :
Electromagnetic Field Computation, 2006 12th Biennial IEEE Conference on
Conference_Location :
Miami, FL
Print_ISBN :
1-4244-0320-0
DOI :
10.1109/CEFC-06.2006.1633100
