Neurochemical thermostat: A neural interface SoC with integrated chemometrics for closed-loop regulation of brain dopamine

Author

Bozorgzadeh, Bardia ; Schuweiler, Douglas ; Bobak, Martin ; Garris, Paul A. ; Mohseni, Pedram

Author_Institution

EECS Dept., Case Western Reserve Univ., Cleveland, OH, USA

fYear

2015

fDate

17-19 June 2015

Abstract

A 3.3 × 3.2mm² SoC in 0.35μm 2P/4M CMOS combines neurochemical sensing, on-the-fly chemometrics, and feedback-controlled stimulation to realize a “neurochemical thermostat” by differentiating electrically evoked brain dopamine levels from interferents in complex signals recorded in vivo and maintaining the levels between two user-set thresholds via closed-loop neuromodulation. The SoC features duty cycling in intermittent neurochemical sensing and digital signal processing to dissipate 127.5μW at 2.5V.

Keywords

CMOS digital integrated circuits; biomedical electronics; biosensors; brain; chemical variables measurement; signal processing; system-on-chip; thermostats; CMOS; brain dopamine levels; closed-loop neuromodulation; closed-loop regulation; digital signal processing; feedback-controlled stimulation; integrated chemometrics; neural interface SoC; neurochemical sensing; neurochemical thermostat; power 127.5 muW; size 0.35 mum; size 3.2 mm; size 3.3 mm; system-on-chip; voltage 2.5 V; CMOS integrated circuits; In vivo; Power capacitors; Program processors; Sensors; System-on-chip; Thermostats;

fLanguage

English

Publisher

ieee

Conference_Titel

VLSI Circuits (VLSI Circuits), 2015 Symposium on

Conference_Location

Kyoto

Print_ISBN

978-4-86348-502-0

Type

conf

DOI

10.1109/VLSIC.2015.7231343

Filename

7231343