Alzheimer disease detection and analysis using P3 component of ERP in Alzheimer type dementia

This study is to develop the Alzheimer´s disease (AD) detection and analysis system using event-related potential (ERP) of AD patients. We recorded ERP in an auditory oddball task in mild AD (n=25), severe AD (n=12), age-matched normal aged controls (n=17), and young controls (n=7). The amplitude and latency of target P3 components were compared among 4 groups. The relationship between P3 measures and neuro psychological test scores were evaluated by correlations. The latency of the target P3a and P3b was prolonged in AD and the effects were correlated with the severity of dementia. The P3 amplitude was not affected significantly in AD. There´s no difference between normal aged group and young group. These results suggest that the P3 component is specifically affected by Alzheimer type dementia.