Title :
Microfluidic chip coupled with optical molecular imaging for behavior analysis
Author :
Liu, Bi-Feng ; Wang, Jingjing ; Feng, Xiaojun ; Du, Wei
Author_Institution :
Dept. of Syst. Biol., Huazhong Univ. of Sci. & Technol., Wuhan, China
Abstract :
We demonstrate a microfluidic system allowing stable immobilization of young adult C. elegans for neuronal and behavior analysis upon chemical stimulations. Chemical stimuli were delivered to the head of the animal by rapid interface shifting of laminar flows and neuronal activities could then be monitored by in vivo Ca2+ imaging.
Keywords :
bioMEMS; biochemistry; biomedical optical imaging; lab-on-a-chip; microfluidics; microorganisms; neurophysiology; behavior analysis; chemical stimuli; in vivo Ca2+ imaging; laminar flows; microfluidic chip; neuronal analysis; optical molecular imaging; rapid interface shifting; young adult C. elegans immobilization; Animals; Chemicals; Imaging; In vivo; Microfluidics; Neurons;
Conference_Titel :
Communications and Photonics Conference and Exhibition (ACP), 2010 Asia
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-7111-9
DOI :
10.1109/ACP.2010.5682690
