Title :
Clinical translation of UV autofluorescence microscopy towards endomicroscopy for early detection of cancer
Author :
Lin, Bevin ; Urayama, Shiro ; Saroufeem, Ramez M.G. ; Matthews, Dennis L. ; Demos, Stavros G.
Author_Institution :
NSF Center for Biophotonics Sci. & Technol., Univ. of California, Davis, Sacramento, CA, USA
Abstract :
The non-invasiveness of autofluorescence technology may reduce sampling error and time delay for histopathology diagnosis. We establish biophotonic methods and guidelines to visualize and interpret early epithelial tissue changes that signify disease. Flexible and rigid fiber endomicroscopy instrumentation design parameters feasible for translation towards clinical use are in development.
Keywords :
bio-optics; biomedical optical imaging; cancer; endoscopes; fluorescence; optical microscopy; patient diagnosis; UV autofluorescence microscopy; biophotonic methods; cancer detection; epithelial tissue changes; flexible fiber endomicroscopy; histopathology diagnosis; rigid fiber endomicroscopy; sampling error; time delay; Endoscopes; Gold; In vivo; Microscopy; Prototypes; Real time systems;
Conference_Titel :
Communications and Photonics Conference and Exhibition (ACP), 2010 Asia
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-7111-9
DOI :
10.1109/ACP.2010.5682843
