Influence of skull inhomogeneities on EEG source localization

We investigated the influence of using simplified models of the skull on electroencephalogram (EEG) source localization. An accurately segmented skull from computed tomography (CT) images, including spongy and compact bones as well as some air-filled cavities, was used as a reference model. The simplified models approximated the skull as a homogeneous compartment with: (1) isotropic, and (2) anisotropic conductivity. The results showed that these approximations could lead to errors of more than 2 cm in dipole estimation. We recommend the use of anisotropy but considering a different ratio for each region of the skull, according to the amount of spongy bone.