Title :
Investigation of collagen changes in sclerodermatous skin using second harmonic generation microscopy
Author :
Lu, Kecheng ; Chen, Jianxin ; Zhuo, Shuangmu ; Zheng, Liqin ; Jiang, Xingshan ; Zhu, Xiaoqin ; Zhao, Jingjun
Author_Institution :
Fujian Provincial Key Lab. for Photonics Technol., Fujian Normal Univ., Fuzhou, China
Abstract :
The changes of collagen in sclerodermatous skin were investigated qualitatively and quantitatively using second harmonic generation (SHG) microscopy. The technique has great potential to be used to diagnose scleroderma and monitor the therapy response.
Keywords :
optical harmonic generation; optical microscopy; proteins; skin; collagen changes; sclerodermatous skin; second harmonic generation microscopy; Biomedical imaging; Dermis; Educational technology; Epidermis; Fast Fourier transforms; Frequency conversion; Laboratories; Laser excitation; Microscopy; Skin; collagen; localized scleroderma; second harmonic generation;
Conference_Titel :
Lasers & Electro Optics & The Pacific Rim Conference on Lasers and Electro-Optics, 2009. CLEO/PACIFIC RIM '09. Conference on
Conference_Location :
Shanghai
Print_ISBN :
978-1-4244-3829-7
Electronic_ISBN :
978-1-4244-3830-3
DOI :
10.1109/CLEOPR.2009.5292663
