DocumentCode :
1982791
Title :
Bioprinted nanoparticles for tissue engineering
Author :
Buyukhatipoglu, Kivilcim ; Chang, Robert ; Sun, Wei ; Clyne, Alisa Morss
Author_Institution :
Mech. Eng. & Mech., Drexel Univ., Philadelphia, PA
fYear :
2009
fDate :
11-13 May 2009
Firstpage :
234
Lastpage :
237
Abstract :
Tissue engineering may require recreation of the complex, three-dimensional native tissue architecture. While bioprinting allows cell and bioactive factor deposition in a precise pattern, it remains difficult to manipulate and track cells and bioactive factors after printing. We now show that superparamagnetic nanoparticles can be printed in an alginate hydrogel or inside cells themselves with low cell toxicity. Both nanoparticles and cells loaded with nanoparticles can be moved within the alginate hydrogel using a low field magnet, and nanoparticles can be imaged within the three-dimensional structure by micro-computed tomography. These data suggest that nanoparticles may advance biomanufacturing capabilities.
Keywords :
computerised tomography; hydrogels; nanoparticles; superparamagnetism; tissue engineering; alginate hydrogel; biomanufacturing capabilities; bioprinted nanoparticles; micro-computed tomography; superparamagnetic nanoparticles; three-dimensional native tissue architecture; tissue engineering; Biological tissues; In vivo; Iron; Magnetic fields; Magnetic resonance imaging; Nanoparticles; Printing; Sun; Tissue engineering; Tomography; alginate; biomanufacturing; endothelial cells; superparamagnetic nanoparticles; tissue engineering;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Computational Intelligence for Measurement Systems and Applications, 2009. CIMSA '09. IEEE International Conference on
Conference_Location :
Hong Kong
Print_ISBN :
978-1-4244-3819-8
Electronic_ISBN :
978-1-4244-3820-4
Type :
conf
DOI :
10.1109/CIMSA.2009.5069956
Filename :
5069956
Link To Document :
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