Title :
A VOM based gene-finder that specializes in short genes
Author :
Shohat-Zaidenraise, K.-O. ; Shmilovici, Armin ; Ben-Gal, Irad
Author_Institution :
Dept. of Ind. Eng., Tel Aviv Univ., Ramat-Aviv, Israel
Abstract :
We present a new approach for gene finding based on a variable-order Markov (VOM) model. The VOM model is a generalization of the traditional Markov model; it is more efficient in terms of its parameterization, and, thus, can be trained on relatively short sequences. As a result, the proposed VOM gene-finder outperforms traditional gene-finders that are based on fifth-order Markov models for short newly sequenced bacterial genomes.
Keywords :
DNA; Markov processes; biology computing; learning (artificial intelligence); microorganisms; pattern recognition; DNA sequences; bacterial genomes; bioinformatics; computational biology; fifth-order Markov models; gene-finder; genomic sequence; protein-coding regions; variable-order Markov model; Bioinformatics; Biological system modeling; Computational biology; Context modeling; DNA; Evolution (biology); Genomics; Microorganisms; Phase estimation; Sequences;
Conference_Titel :
Electrical and Electronics Engineers in Israel, 2004. Proceedings. 2004 23rd IEEE Convention of
Print_ISBN :
0-7803-8427-X
DOI :
10.1109/EEEI.2004.1361121