DocumentCode :
1988578
Title :
Correlation of Microcirculatory Parameters Derived from the Generalized Kinetic and Distributed Parameter Models: A Perfusion CT Study
Author :
Li, T.H. ; Koh, T.S. ; Thng, C.H. ; Wei, X.Y. ; Zhao, J.H. ; Cheong, L.H.D. ; Lim, C.C.T.
Author_Institution :
Sch. of Electr. & Electron. Eng., Nanyang Technol. Univ., Singapore, Singapore
fYear :
2012
fDate :
27-30 May 2012
Firstpage :
1
Lastpage :
4
Abstract :
Dynamic contrast-enhanced (DCE) imaging is a functional imaging technique that can be used to assess tumor angiogenesis and yields quantitative estimates of tissue microcirculatory parameters by tracer kinetic model analysis. In this study, we explored the possible relationships between parameters of two tracer kinetic models, the generalized kinetic and distributed parameter models, by comparing these models on DCE CT datasets of actual patient study cases. Understanding the use of these models and the physiological meaning of their parameters would improve the interpretation and assessment of anti-angiogenic drug trials by DCE imaging.
Keywords :
brain; computerised tomography; haemorheology; kinetic theory; tumours; DCE CT datasets; actual patient cases; antiangiogenic drug trials; blood flow; brain tissue microcirculatory parameter correlation; distributed parameter model; dynamic contrast-enhanced imaging; functional imaging method; generalized tracer kinetic model analysis; perfusion CT study; physiological meaning; tumor angiogenesis; Blood flow; Brain; Computed tomography; Drugs; Kinetic theory; Permeability; Tumors;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering and Technology (S-CET), 2012 Spring Congress on
Conference_Location :
Xian
Print_ISBN :
978-1-4577-1965-3
Type :
conf
DOI :
10.1109/SCET.2012.6341926
Filename :
6341926
Link To Document :
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