Title :
Latex piezoelectric immunoassay: it´s application for clinical and environmental analysis
Author :
Kurosawa, Shigeru ; Muratsugu, Makoto ; Nakamura, Chikashi ; Aizawa, Hidenobu ; Minoura, Norihiko ; Miyake, Jun ; Yoshimoto, Minoru ; Kamo, Naoki
Author_Institution :
Nat. Inst. for Adv. Interdisciplinary Res., Tsukuba, Japan
Abstract :
Latex piezoelectric immunoassay (LPEIA) is a new immunoassay method that requires no immobilization of antigen or antibody on the electrode surface of quartz crystal, in contrast to previous immunoassays in which a piezoelectric crystal is used as a microbalance and immobilization is essential. The frequency change was observed during the aggregation of antibody- or antigen-coated latex particles. This method was used for the detection and is sufficiently sensitive for clinical applications. We made a prototype LPEIA sensor for remote sensing and diagnosis to care for a handicapped person in their home
Keywords :
biochemistry; biosensors; crystal resonators; microbalances; patient diagnosis; patient monitoring; proteins; LPEIA; antibody-coated latex particles; antigen-coated latex particles; clinical applications; electrode surface; environmental analysis; frequency change; latex piezoelectric immunoassay; quartz crystal; Chemicals; Electrodes; Frequency; Humans; Immune system; Piezoelectric films; Proteins; Prototypes; Remote monitoring; Testing;
Conference_Titel :
Frequency and Time Forum, 1999 and the IEEE International Frequency Control Symposium, 1999., Proceedings of the 1999 Joint Meeting of the European
Conference_Location :
Besancon
Print_ISBN :
0-7803-5400-1
DOI :
10.1109/FREQ.1999.841475
