• DocumentCode
    1988962
  • Title

    Finding higher order motifs under the levenshtein measure

  • Author

    Adebiyi, Ezekiel F. ; Dipe, Tinuke

  • Author_Institution
    Dept. of Math. & Comput. Sci., Ilorin Univ., Nigeria
  • fYear
    2003
  • fDate
    11-14 Aug. 2003
  • Firstpage
    583
  • Lastpage
    584
  • Abstract
    We study the problem of finding higher order motifs under the levenshtein measure, otherwise known as the edit distance. In the problem set-up, we are given N sequences, each of average length n, over a finite alphabet Σ and thresholds D and q, we are to find composite motifs that contain motifs of length P (these motifs occur with almost D differences) in 1 ≤ q ≤ N distinct sequences. Two interesting but involved algorithms for finding higher order motifs under the edit distance was presented by Marsan and Sagot. Their second algorithm is much more complicated and its complexity is asymptotically not better. Their first algorithm runs in O(M · N2n1+α ·p · pow(ε)) where p ≥ 2, α > 0, pow(ε) is a concave function that is less than 1, ε= D/P and M is the expected number of all monad motifs. We present an alternative algorithmic approach also for Edit distance based on the concept described. The resulting algorithm is simpler and runs in O(N2n1+p · pow(ε)) expected time.
  • Keywords
    DNA; biology computing; concave function; edit distance; first algorithm; higher order motifs; levenshtein measure; monad motifs; second algorithm; Bioinformatics; Biological processes; Computational biology; Computer science; DNA; Hamming distance; Mathematics; Measurement units; Organisms; Random sequences;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioinformatics Conference, 2003. CSB 2003. Proceedings of the 2003 IEEE
  • Print_ISBN
    0-7695-2000-6
  • Type

    conf

  • DOI
    10.1109/CSB.2003.1227414
  • Filename
    1227414