DocumentCode
1988962
Title
Finding higher order motifs under the levenshtein measure
Author
Adebiyi, Ezekiel F. ; Dipe, Tinuke
Author_Institution
Dept. of Math. & Comput. Sci., Ilorin Univ., Nigeria
fYear
2003
fDate
11-14 Aug. 2003
Firstpage
583
Lastpage
584
Abstract
We study the problem of finding higher order motifs under the levenshtein measure, otherwise known as the edit distance. In the problem set-up, we are given N sequences, each of average length n, over a finite alphabet Σ and thresholds D and q, we are to find composite motifs that contain motifs of length P (these motifs occur with almost D differences) in 1 ≤ q ≤ N distinct sequences. Two interesting but involved algorithms for finding higher order motifs under the edit distance was presented by Marsan and Sagot. Their second algorithm is much more complicated and its complexity is asymptotically not better. Their first algorithm runs in O(M · N2n1+α ·p · pow(ε)) where p ≥ 2, α > 0, pow(ε) is a concave function that is less than 1, ε= D/P and M is the expected number of all monad motifs. We present an alternative algorithmic approach also for Edit distance based on the concept described. The resulting algorithm is simpler and runs in O(N2n1+p · pow(ε)) expected time.
Keywords
DNA; biology computing; concave function; edit distance; first algorithm; higher order motifs; levenshtein measure; monad motifs; second algorithm; Bioinformatics; Biological processes; Computational biology; Computer science; DNA; Hamming distance; Mathematics; Measurement units; Organisms; Random sequences;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics Conference, 2003. CSB 2003. Proceedings of the 2003 IEEE
Print_ISBN
0-7695-2000-6
Type
conf
DOI
10.1109/CSB.2003.1227414
Filename
1227414
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