DocumentCode
1990964
Title
Bottom-Up Multiple Row Addition Algorithms for the Biclustering-Problem
Author
Koh, Hyung-Won ; Hildebrand, Lars
Author_Institution
Inst. for Anal. Sci., Dortmund
fYear
2007
fDate
14-17 Oct. 2007
Firstpage
849
Lastpage
856
Abstract
The discovery of locally and significantly correlated subpatterns within a two-dimensional dataset has recently become quite popular and is amongst others addressed by methods solving the biclustering problem. The preservation of a particularly defined degree of homogeneity between elements within a bicluster plays a key role in the search procedure. A prominent quantity is known as the mean squared residue. Most approaches use such measures only to evaluate the found solutions a posteriori, instead of incorporating them directly into the search procedure. This work proposes a pairwise distance function related to the mean squared residue and includes this measure into two new multiple enrichment algorithms. The impact is demonstrated empirically by the enrichment of bicluster sets of a popular method and by the enrichment of randomly chosen single rows.
Keywords
biology computing; genetics; biclustering problem; bottom-up multiple row addition algorithms; gene expression; mean squared residue; multiple enrichment algorithms; pairwise homogeneity distance function; Algorithm design and analysis; Biological processes; Clustering algorithms; Costs; Evolutionary computation; Gene expression; Instruction sets; Iterative methods; Parameter estimation; Particle measurements;
fLanguage
English
Publisher
ieee
Conference_Titel
Bioinformatics and Bioengineering, 2007. BIBE 2007. Proceedings of the 7th IEEE International Conference on
Conference_Location
Boston, MA
Print_ISBN
978-1-4244-1509-0
Type
conf
DOI
10.1109/BIBE.2007.4375659
Filename
4375659
Link To Document