• DocumentCode
    1990964
  • Title

    Bottom-Up Multiple Row Addition Algorithms for the Biclustering-Problem

  • Author

    Koh, Hyung-Won ; Hildebrand, Lars

  • Author_Institution
    Inst. for Anal. Sci., Dortmund
  • fYear
    2007
  • fDate
    14-17 Oct. 2007
  • Firstpage
    849
  • Lastpage
    856
  • Abstract
    The discovery of locally and significantly correlated subpatterns within a two-dimensional dataset has recently become quite popular and is amongst others addressed by methods solving the biclustering problem. The preservation of a particularly defined degree of homogeneity between elements within a bicluster plays a key role in the search procedure. A prominent quantity is known as the mean squared residue. Most approaches use such measures only to evaluate the found solutions a posteriori, instead of incorporating them directly into the search procedure. This work proposes a pairwise distance function related to the mean squared residue and includes this measure into two new multiple enrichment algorithms. The impact is demonstrated empirically by the enrichment of bicluster sets of a popular method and by the enrichment of randomly chosen single rows.
  • Keywords
    biology computing; genetics; biclustering problem; bottom-up multiple row addition algorithms; gene expression; mean squared residue; multiple enrichment algorithms; pairwise homogeneity distance function; Algorithm design and analysis; Biological processes; Clustering algorithms; Costs; Evolutionary computation; Gene expression; Instruction sets; Iterative methods; Parameter estimation; Particle measurements;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Bioinformatics and Bioengineering, 2007. BIBE 2007. Proceedings of the 7th IEEE International Conference on
  • Conference_Location
    Boston, MA
  • Print_ISBN
    978-1-4244-1509-0
  • Type

    conf

  • DOI
    10.1109/BIBE.2007.4375659
  • Filename
    4375659