• DocumentCode
    1991920
  • Title

    Reduction cost for Boolean Networks with perturbation

  • Author

    Dougherty, John ; Ivanov, Ivan

  • Author_Institution
    Dept. of Signal Process., Tampere Univ. of Technol., Tampere
  • fYear
    2008
  • fDate
    8-10 June 2008
  • Firstpage
    1
  • Lastpage
    3
  • Abstract
    A serious obstacle in applying computational models of genomic regulation is their complexity. Thus, there is a need for size reducing mappings that preserve biologically meaningful properties of the models. There are several available reduction mappings for the PBN model that are capable of preserving important structural or dynamical properties of the network. However, the cost of applying such mappings has been largely ignored. This paper studies how the notion of stochastic complexity can be used to measure the cost of reduction in the case of a specific class of constrained reduction mappings.
  • Keywords
    Boolean functions; biology computing; cellular biophysics; genetics; molecular biophysics; stochastic processes; PBN reduction mappings; constrained reduction mappings; genomic regulation computational model; perturbed boolean network cost reduction; size reducing mappings; stochastic complexity; Bioinformatics; Biological system modeling; Biology computing; Biomedical signal processing; Computational modeling; Costs; Gene expression; Genomics; Physiology; Stochastic processes;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Genomic Signal Processing and Statistics, 2008. GENSiPS 2008. IEEE International Workshop on
  • Conference_Location
    Phoenix, AZ
  • Print_ISBN
    978-1-4244-2371-2
  • Electronic_ISBN
    978-1-4244-2372-9
  • Type

    conf

  • DOI
    10.1109/GENSIPS.2008.4555674
  • Filename
    4555674