Title :
Reduction cost for Boolean Networks with perturbation
Author :
Dougherty, John ; Ivanov, Ivan
Author_Institution :
Dept. of Signal Process., Tampere Univ. of Technol., Tampere
Abstract :
A serious obstacle in applying computational models of genomic regulation is their complexity. Thus, there is a need for size reducing mappings that preserve biologically meaningful properties of the models. There are several available reduction mappings for the PBN model that are capable of preserving important structural or dynamical properties of the network. However, the cost of applying such mappings has been largely ignored. This paper studies how the notion of stochastic complexity can be used to measure the cost of reduction in the case of a specific class of constrained reduction mappings.
Keywords :
Boolean functions; biology computing; cellular biophysics; genetics; molecular biophysics; stochastic processes; PBN reduction mappings; constrained reduction mappings; genomic regulation computational model; perturbed boolean network cost reduction; size reducing mappings; stochastic complexity; Bioinformatics; Biological system modeling; Biology computing; Biomedical signal processing; Computational modeling; Costs; Gene expression; Genomics; Physiology; Stochastic processes;
Conference_Titel :
Genomic Signal Processing and Statistics, 2008. GENSiPS 2008. IEEE International Workshop on
Conference_Location :
Phoenix, AZ
Print_ISBN :
978-1-4244-2371-2
Electronic_ISBN :
978-1-4244-2372-9
DOI :
10.1109/GENSIPS.2008.4555674