Title :
A 16-channel low-noise programmable system for the recording of neural signals
Author :
López, Carolina Mora ; Braeken, Dries ; Bartic, Carmen ; Puers, Robert ; Gielen, Georges ; Eberle, Wolfgang
Author_Institution :
Imec, Leuven, Belgium
Abstract :
The current migration from passive to active neuroprobes, the increasing density in multielectrode arrays, as well as the introduction of new materials and processes for electrode fabrication, are imposing important challenges on the implementation of optimal integrated neural recording systems. In this paper, we present the design and implementation of an integrated neural acquisition system with 16 fully-differential input channels with individual channel programmability for the recording of neural activity in in vitro and in vivo experiments. Each channel consists of ac-coupled low-power, low-noise programmable amplification (from 100 to 6000 V/V) and programmable band-pass filtering, achieving 37nV/√Hz input-referred noise density while consuming a maximum of 70 μA per channel from a single 3.3V. The ASIC was implemented in a 0.35 μm CMOS technology and has a total area of 5.6 × 4.5 mm2. The system has been successfully tested in in vitro experiments, achieving simultaneous extracellular recordings of action potentials and showing satisfactory signal-to-noise ratios.
Keywords :
CMOS digital integrated circuits; application specific integrated circuits; band-pass filters; cellular biophysics; integrated circuit noise; low-power electronics; medical signal processing; microelectrodes; neurophysiology; programmable filters; 16-channel low-noise programmable system; ASIC; CMOS technology; ac-coupled low-power programmable amplification; action potential; extracellular recording; in-vitro experiment; in-vivo experiment; integrated neural acquisition system; low-noise programmable amplification; multielectrode arrays; neural signal recording; programmable band-pass filtering; signal-to-noise ratio; size 0.35 mum; Band pass filters; Capacitors; Electrodes; Gain; In vitro; Low pass filters; Noise;
Conference_Titel :
Circuits and Systems (ISCAS), 2011 IEEE International Symposium on
Conference_Location :
Rio de Janeiro
Print_ISBN :
978-1-4244-9473-6
Electronic_ISBN :
0271-4302
DOI :
10.1109/ISCAS.2011.5937847