Probability Analysis on Associations of Adverse Drug Events with Drug-Drug Interactions

Adverse drug reaction (ADR) may cost a lot of unnecessary medical resources and leads to extra suffering on patients. To provide the prompt information about ADR and avoid the rate of occurrence of ADR is an important task yet to be done. The US Food and Drug Administration (FDA) provides a Adverse Event Reporting System (AERS) which contains a lot of clinical reports about ADRs. However, the biologists still do not know precisely which observed events are directly caused by drug-drug interactions. We use the probability analysis method to find the associations between a set of drugs and the symptoms for predicting the ADR and apply the decision tree to discovery the association rules between the drug-drug interactions and symptoms.