Intelligent interpretation of PCR products in 1D gels for automatic molecular diagnostics

Author

Pathak, Dhiraj K. ; Perlin, Mark W.

Author_Institution

Sch. of Comput. Sci., Carnegie Mellon Univ., Pittsburgh, PA, USA

fYear

1994

fDate

10-12 Jun 1994

Firstpage

94

Lastpage

97

Abstract

An important step in molecular diagnostics for genetic diseases is the interpretation of sizing signals obtained by gel electrophoresis. Usually, the interpretation is done manually and is labor-intensive. An algorithm for automatic interpretation of two-dimensional sizing signals is described. The underlying computation is a rule-based assignment of values to labels of a set of image variables

Keywords

DNA; cellular biophysics; electrophoresis; gels; knowledge based systems; medical diagnostic computing; medical signal processing; molecular biophysics; patient diagnosis; 1D gels; 2D sizing signals; PCR products; algorithm; automatic interpretation; automatic molecular diagnostics; gel electrophoresis; genetic diseases; image variables; intelligent interpretation; rule-based assignment of values; Bioinformatics; Computer science; DNA; Diseases; Electrokinetics; Fluorescence; Genetics; Genomics; Humans; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Computer-Based Medical Systems, 1994., Proceedings 1994 IEEE Seventh Symposium on

Conference_Location

Winston-Salem, NC

Print_ISBN

0-8186-6256-5

Type

conf

DOI

10.1109/CBMS.1994.315994

Filename

315994